Synjardy 2025 Price & Side Effects: Essential Guide for Managing Type 2 Diabetes

Overview of Synjardy for Type 2 Diabetes

Synjardy, combining empagliflozin and metformin, is a prescription oral medication designed for adults managing type 2 diabetes. It not only helps regulate blood glucose levels but also plays a crucial role in lowering the risk of cardiovascular death among patients with existing heart disease.

Available in two formulations, Synjardy immediate-release tablets are taken twice daily, while Synjardy XR extended-release tablets offer once-daily convenience with gradual drug release for better tolerance.

Common Side Effects: What to Expect

While Synjardy effectively supports diabetes management, users may experience side effects ranging from mild to serious. Frequently reported mild side effects include:

• Diarrhea
• Nausea and vomiting
• Indigestion or upset stomach
• Weakness and headaches
• Urinary tract infections (UTIs)
• Genital yeast infections*

These symptoms often diminish over time or can be managed with medical advice. Not every patient will experience these, but awareness is key.

Mild Side Effects in Detail

Additional mild side effects may consist of increased urination, abdominal discomfort, flatulence, upper respiratory infections like the common cold, vitamin B12 deficiency, and joint pain. Persistent or bothersome symptoms should be discussed with your healthcare provider.

Serious Side Effects: Immediate Attention Needed

Some rare but severe side effects linked to Synjardy require prompt medical intervention, including:

• Hypoglycemia, especially when combined with insulin or sulfonylureas
• Severe UTIs such as pyelonephritis or urosepsis
• Lactic acidosis – a potentially fatal accumulation of lactic acid
• Low blood pressure and kidney complications
• Ketoacidosis
• Fournier's gangrene – a serious genital infection
• Allergic reactions with symptoms like swelling or breathing difficulties

In the event of severe symptoms, seek emergency care immediately.

Frequently Asked Questions About Synjardy Side Effects

Does the 12.5 mg/1,000 mg dose increase side effect risks?

Higher doses may slightly elevate the likelihood of side effects. The 12.5 mg/1,000 mg tablet is the highest strength for immediate-release Synjardy, taken twice daily. Always follow your doctor’s dosing recommendations and discuss any concerns.

Can Synjardy cause sexual side effects in women?

Synjardy does not typically cause sexual dysfunction in females. However, genital yeast infections caused by the medication can lead to discomfort during intercourse. Prompt treatment with antifungal therapies is advised.

Are side effects different between Synjardy and Synjardy XR?

Both forms contain the same active ingredients and can cause similar side effects. Synjardy XR’s extended-release formulation may reduce gastrointestinal symptoms like nausea and diarrhea due to slower drug absorption.

How long do side effects last?

Mild side effects often fade within days to weeks. Serious side effects improve with appropriate medical care. Discuss any persistent symptoms with your healthcare provider.

How to reduce the risk of urinary tract infections?

Preventive measures include staying well-hydrated, maintaining genital hygiene, urinating after intercourse, avoiding scented products, and wearing breathable cotton underwear. Consult your doctor promptly if UTI symptoms arise.

Important Synjardy Warnings

Boxed Warning: Lactic Acidosis

Synjardy carries a FDA boxed warning for lactic acidosis, a rare but life-threatening condition requiring immediate hospitalization.

Precautions

Before starting Synjardy, inform your doctor if you have kidney or liver issues, are over 65 years old, have a history of metabolic acidosis, recurrent yeast infections, or pancreatic problems. Avoid excessive alcohol consumption while on Synjardy to minimize risks.

Pregnancy and Breastfeeding

Synjardy is not recommended during the second and third trimesters of pregnancy and should be avoided while breastfeeding. Consult your healthcare provider for safer alternatives if you are pregnant or nursing.

Understanding Key Side Effects

Lactic Acidosis

Symptoms include extreme tiredness, muscle pain, abdominal discomfort, breathing difficulties, and irregular heartbeat. Stay hydrated and inform your doctor about any upcoming surgeries or imaging tests that require contrast agents.

Genital Yeast Infections

Signs include itching, redness, and abnormal discharge. Over-the-counter antifungal creams or prescription medications can effectively treat these infections. Preventive strategies help reduce recurrence.

Ketoacidosis

Watch for nausea, vomiting, abdominal pain, shortness of breath, and fruity breath odor. This serious condition demands immediate medical care.

Fournier’s Gangrene

Rare but severe, this infection causes genital pain, swelling, and fever. Urgent hospital treatment is critical.

Allergic Reactions

Mild reactions such as rash can be managed by your doctor, but severe symptoms like swelling or breathing difficulty require emergency attention.

Tips for Managing Side Effects

Keep a detailed log of any side effects, including dosage, timing, symptoms, and impact on daily life. Sharing this with your healthcare provider will help tailor your treatment plan for optimal safety and effectiveness.

Questions to Discuss with Your Doctor

• What is my risk of lactic acidosis or infections while taking Synjardy?
• Should I adjust my dose if side effects occur?
• Do I need to stop Synjardy before surgeries or certain medical tests?
• What strategies can help prevent or manage side effects?

Consult a Pharmacist

Can other medications increase side effect risks?

Combining Synjardy with insulin or sulfonylureas may increase hypoglycemia risk. Diuretics may enhance dehydration risks. Some heart, cancer, and HIV medications can elevate metformin levels, increasing lactic acidosis risk. Always inform your healthcare team about all medications you're taking.

Disclaimer: This article provides informational content based on current research as of 2024 and should not replace professional medical advice. Consult your healthcare provider for personalized recommendations.

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