Orserdu 2025 Price, Dosage Guidelines, Side Effects & Interactions Explained

Orserdu (elacestrant) is a prescription oral medication designed to treat specific types of breast cancer in adults. It belongs to hormone therapy drugs and is administered as a tablet taken by mouth.

Orserdu targets estrogen receptor-positive, HER2-negative breast cancer with ESR1 gene mutations in adults. It is prescribed for cancers that have advanced or metastasized and have progressed despite prior hormone therapy treatment.

Note: ESR1 mutation refers to a genetic alteration in the cancer cells. Advanced cancer indicates spread within the chest or nearby areas, while metastatic means the cancer has spread further in the body.

Key Facts About Orserdu

Containing the active compound elacestrant, Orserdu works by blocking estrogen receptors on cancer cells to inhibit tumor growth. Currently, no generic versions are available, making Orserdu a branded medication.

Common and Serious Side Effects of Orserdu

Like all medications, Orserdu may cause side effects ranging from mild to severe. Side effects can vary based on individual factors such as age, health conditions, and other medications.

Mild Side Effects

• Muscle or body aches
• Nausea and vomiting
• Fatigue or low energy
• Loss of appetite
• Diarrhea or constipation
• Headaches
• Abdominal pain
• Hot flashes
• Indigestion
• Mild allergic reactions like rash or itching

Mild symptoms often resolve within days or weeks, but consult your healthcare provider if they persist or worsen.

Serious Side Effects

• Elevated cholesterol and triglycerides (lipid disorders)
• Increased liver enzymes indicating possible liver issues
• Abnormal kidney function test results
• Severe allergic reactions including swelling and breathing difficulties

If you experience serious side effects, seek immediate medical attention.

Allergic Reactions

Though rare, severe allergic reactions to Orserdu can occur. Symptoms include swelling of the face, lips, tongue, or throat and difficulty breathing. Mild allergic reactions may present as skin rash, itchiness, or flushing.

Contact your doctor promptly if you notice any allergic symptoms. In emergencies, call 911 or your local emergency number.

Orserdu Cost and Savings Options in 2024

The price of Orserdu may vary depending on your insurance coverage, pharmacy, and treatment plan. To reduce out-of-pocket costs, you can explore savings coupons on platforms like Optum Perks. Note that these coupons cannot be combined with insurance benefits.

Additionally, patient assistance programs such as Stemline ARC may provide financial support. Discuss cost-saving options with your healthcare provider or pharmacist.

Approved Uses of Orserdu

Orserdu is prescribed for postmenopausal females and adult males with breast cancer characterized by:

• Estrogen receptor-positive (ER+)
• HER2-negative
• ESR1 gene mutation
• Advanced or metastatic stage
• Progression after at least one prior hormone therapy, such as fulvestrant (Faslodex)

By blocking estrogen receptors, Orserdu helps slow or stop tumor growth fueled by estrogen.

Frequently Asked Questions About Orserdu

Is Orserdu a chemotherapy drug?

No, Orserdu is a hormone therapy, not chemotherapy. Unlike chemotherapy, which kills rapidly dividing cells, hormone therapy blocks hormone effects to inhibit cancer growth.

Does Orserdu cause long-term side effects?

Long-term side effects have not been observed in clinical studies. However, Orserdu may impact fertility based on animal research. Discuss family planning concerns with your doctor before starting treatment.

How does Orserdu compare to Faslodex?

Both are hormone therapies for breast cancer, but Orserdu is effective against cancers resistant to Faslodex. Orserdu is taken orally once daily, while Faslodex is administered via monthly injections.

Dosage Information for Orserdu

Orserdu is available in 86 mg and 345 mg oral tablets. The typical dose is 345 mg once daily with food.

Your doctor may adjust or pause your dosage if side effects occur, especially in cases of liver impairment.

Important Usage Tips

• Swallow tablets whole; do not chew, crush, or split.
• Take with food to reduce nausea.
• Maintain a consistent daily schedule.
• If a dose is missed by more than 6 hours, skip it and resume the next day.
• Vomiting after taking a dose does not require repeating it.
• Orserdu is generally a long-term treatment.

Overdose Guidance

Do not exceed the prescribed dose. If overdose is suspected, contact your healthcare provider or poison control immediately. In emergencies, call 911 or visit the nearest emergency room.

Precautions and Interactions to Know Before Taking Orserdu

Drug and Food Interactions

Orserdu may interact with medications that influence liver enzymes, such as itraconazole or rifampin. It may also interact with supplements like St. John's wort and foods like grapefruit or grapefruit juice. Always inform your doctor about all substances you are taking.

Alcohol Use

There are no known interactions between Orserdu and alcohol, but consult your doctor to confirm if alcohol consumption is safe during your treatment.

Pregnancy and Breastfeeding

Orserdu is not safe during pregnancy or breastfeeding. It is intended for use only in postmenopausal females and adult males. Effective contraception is recommended for patients who can conceive during and for at least one week after treatment.

Important Warnings

Inform your healthcare provider if you have liver problems, previous allergic reactions to Orserdu, are pregnant, or breastfeeding before starting treatment.

Alternatives to Orserdu

Other hormone therapies may be considered as alternatives, including fulvestrant (Faslodex), goserelin (Zoladex), anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara). Discuss with your doctor which option suits your condition best.

Questions to Discuss with Your Doctor

• How frequently should I have blood tests during Orserdu treatment?
• Are there any interactions between Orserdu and my current medications or supplements?
• What lifestyle changes can help manage cholesterol and triglyceride levels while on Orserdu?

Stay informed and supported by subscribing to health newsletters and joining communities like Bezzy for peer support.

Disclaimer: This content is for informational purposes and not a substitute for professional medical advice. Always consult your healthcare provider before starting or changing treatment.

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