Endometriosis Blood Tests 2025: Prices & Diagnostic Insights You Need to Know
Gabrielle Kassel
Gabrielle Kassel 2 years ago
Medical & Wellness Contributor #Sexual Wellness
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Endometriosis Blood Tests 2025: Prices & Diagnostic Insights You Need to Know

Discover the latest on blood tests for endometriosis in 2025. Learn why surgical laparoscopy remains the gold standard and explore alternative diagnostic tools with expert insights.

As of 2024, no blood test alone can definitively diagnose endometriosis. Despite ongoing research, the only reliable method for diagnosis remains a surgical procedure known as laparoscopy.

Dr. Monte Swarup, OB-GYN and founder of Vaginal Health Hub, confirms, “Currently, there is no clinically approved blood test that can diagnose endometriosis independently.”

One blood test frequently discussed is the CA-125 test, which measures a protein that may be elevated in individuals with endometriosis. Dr. Laura Purdy, OB-GYN and chief medical officer at Wisp, explains, “While CA-125 levels can be higher in those with endometriosis, this test alone is insufficient for diagnosis due to overlap with other conditions.”

Understanding the CA-125 Test

The CA-125 test evaluates the concentration of the CA-125 protein in the bloodstream. Initially developed to detect certain gynecological cancers, it sometimes indicates the presence of endometriosis when levels are elevated.

However, CA-125 levels can also rise during menstruation, pregnancy, or in benign gynecological conditions, limiting its specificity as a diagnostic tool for endometriosis.

What Does Current Research Indicate?

Researchers agree that while a blood test would offer a more affordable and less invasive diagnostic option, no existing test provides the accuracy necessary to replace laparoscopy.

How Is Endometriosis Diagnosed Today?

Laparoscopy remains the gold standard for endometriosis diagnosis. This minimally invasive surgery involves small abdominal incisions through which a laparoscope—a tiny camera—is inserted to visually inspect internal tissues for signs of endometriosis such as adhesions or lesions.

During the procedure, surgeons may perform biopsies on suspicious tissue to confirm the diagnosis. Most patients return home the same day and can resume normal activities within a few days.

Some clinicians also use imaging techniques like ultrasound or MRI. Ultrasound can detect ovarian endometriomas but cannot identify endometrial tissue elsewhere. MRI is capable of detecting deeper infiltrating endometriosis but is not definitive for all cases.

When Should You Seek Medical Advice?

If you experience symptoms suggestive of endometriosis, consulting a healthcare professional—preferably one specializing in trauma-informed endometriosis care—is essential. Telehealth platforms can also provide access to experienced specialists.

Following evaluation, your provider can recommend appropriate diagnostic steps and treatment options tailored to your needs.

Summary

To date, no blood test can conclusively diagnose endometriosis. Laparoscopy remains the definitive diagnostic method, while ultrasound and MRI serve as supplementary tools. Staying informed and consulting specialized healthcare providers ensures the best path toward diagnosis and management.

Gabrielle Kassel (she/her) is a queer sex educator and wellness journalist dedicated to empowering individuals to embrace their health. Her work has been featured in Healthline, Shape, Cosmopolitan, and more. Outside of writing, Gabrielle enjoys coaching CrossFit, hiking with her border collie, and podcasting. Follow her on Instagram @Gabriellekassel.

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