Zestril (Lisinopril) Side Effects 2025: Costs, Risks, and Management Tips

Zestril, known generically as lisinopril, is a widely prescribed medication for managing heart-related conditions. While effective, it may cause a range of side effects from mild discomforts like headaches and dizziness to more serious health concerns such as high potassium levels or kidney issues.

Zestril is primarily used to:

• Control high blood pressure in adults and children aged 6 and above*
• Treat heart failure in adults†
• Lower the risk of death following a heart attack in adults

Available as oral tablets, Zestril contains lisinopril, the active ingredient responsible for its therapeutic effects.

Continue reading to discover detailed information about Zestril’s side effects, their management, and important safety warnings. For a full overview of the drug’s uses, refer to our dedicated article.

* May be prescribed alone or alongside other blood pressure medications.
† Used as an add-on treatment with other heart failure drugs.

Common Side Effects of Zestril

Patients taking Zestril often report certain side effects, which can vary depending on the condition being treated.

Typical side effects when used for high blood pressure include:

• Persistent dry cough
• Dizziness
• Headache

For heart failure patients, chest pain is more frequently reported, while those recovering from a heart attack may experience low blood pressure.

Mild Side Effects to Watch For

Mild side effects may occur but are generally temporary and manageable. They include:

• Fainting, especially upon standing
• Altered taste or smell
• Blurred or double vision
• Fatigue or weakness
• Itchiness and dry mouth
• Hair thinning
• Constipation or diarrhea
• Ringing in the ears
• Mild allergic reactions*

If these symptoms persist or cause discomfort, consult your healthcare provider. Do not discontinue Zestril without medical advice.

*See the “Side Effects Explained” section for more.

Serious Side Effects and When to Seek Help

Although less common, serious side effects require immediate medical attention:

• Elevated blood potassium levels*
• Bone marrow or blood cell abnormalities (rare)
• Liver dysfunction or failure (rare)
• Reduced kidney function*
• Severe hypotension (low blood pressure)
• Boxed warning: risk of fetal harm during pregnancy†
• Severe allergic reactions including angioedema and anaphylaxis*

If you experience symptoms such as chest pain, difficulty breathing, or swelling of the face and throat, call emergency services immediately.

*Detailed explanations provided below.
† Refer to the pregnancy section for precautions.

FDA Monitoring: The Food and Drug Administration continuously monitors Zestril’s safety profile. To report side effects, visit MedWatch.

Frequently Asked Questions About Zestril Side Effects

Are side effects different between men and women?

Most side effects are similar across sexes. However, erectile dysfunction has been reported in men, and fetal harm concerns apply to women. Men experiencing erectile issues should consult their doctor for treatment options. Women of childbearing age should use effective contraception during treatment.

Can Zestril cause long-term side effects?

Yes, some side effects like dry cough and decreased kidney function may persist during treatment or even after stopping the medication. Regular blood tests are essential to monitor liver, kidney, and blood health.

Does dosage affect side effects?

Higher doses, such as 10 mg compared to 5 mg, may increase the likelihood of side effects like dizziness and low blood pressure. Starting with the lowest effective dose helps minimize risks.

Understanding Key Side Effects

High Blood Potassium (Hyperkalemia)

Symptoms include nausea, irregular heartbeat, tingling sensations, chest pain, and muscle cramps. Risk factors include high-potassium diets, dehydration, kidney disease, and certain medications. Staying hydrated and moderating potassium intake can help manage this risk.

Reduced Kidney Function

Signs include swelling, fatigue, nausea, and changes in urine output. Avoid NSAIDs and maintain hydration. Prompt medical evaluation is crucial if symptoms arise.

Allergic Reactions

Reactions can range from mild rashes to life-threatening angioedema and anaphylaxis. Those with previous ACE inhibitor reactions, African ancestry, or on immunosuppressants may have higher risk. Seek immediate emergency care if severe symptoms occur.

Tracking Side Effects: Keep a detailed log of any symptoms, including dosage, onset, and impact on daily life. Share this with your healthcare provider to optimize your treatment.

Important Safety Warnings

Pregnancy Risks

Zestril carries a boxed warning for fetal harm and should not be used during pregnancy. Women planning pregnancy should discuss alternative treatments and contraception with their doctors.

Other Precautions

Inform your doctor if you have kidney or liver issues, high potassium, low blood pressure, or are on dialysis. Also disclose all medications and supplements to avoid harmful interactions.

Alcohol Interaction

Alcohol may exacerbate side effects like dizziness and headache and can interfere with blood pressure control. Consult your healthcare provider regarding alcohol consumption.

Consult Your Doctor

If you experience side effects or have concerns about Zestril, discuss them with your healthcare professional. Questions to consider include:

• Will Zestril affect my ability to drive?
• When should I report side effects?
• Are there dietary restrictions to consider?

Stay informed and proactive about your heart health by subscribing to trusted health newsletters and joining supportive communities.

Disclaimer: This content is for informational purposes and does not replace professional medical advice. Always consult your healthcare provider before starting or stopping any medication.

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