Unlocking Otezla Interactions: Alcohol, Medications, Supplements & More Explained
Explore in-depth insights into Otezla’s interactions with alcohol, prescription drugs, supplements, and other factors to ensure safe and effective treatment.
Otezla (apremilast) may interact with alcohol, various medications, and certain supplements, influencing its effectiveness and side effects. Notably, drugs like rifampin and some seizure medications can affect how Otezla works in your body.
Administered as an oral tablet, Otezla is prescribed to adults for conditions including:
- Psoriatic arthritis
- Mouth ulcers linked to Behcet’s disease
It also treats plaque psoriasis in adults and children aged 6 and above.
Interactions occur when one substance alters the effect of another or when underlying health conditions influence medication response. Continue reading to discover key interaction details related to Otezla.
Can You Combine Otezla and Alcohol Safely?
Currently, there is no documented direct interaction between Otezla and alcohol. However, alcohol shares side effects with Otezla, such as nausea, headaches, and diarrhea. Consuming alcohol during treatment might heighten these side effects or worsen existing symptoms.
Moreover, alcohol may exacerbate mouth ulcers caused by Behcet’s disease.
Discuss your alcohol consumption habits with your healthcare provider to determine a safe approach while on Otezla.
Otezla and Other Medications: What You Need to Know
Before starting Otezla, inform your doctor and pharmacist about all prescription, over-the-counter drugs, supplements, and herbs you use. This helps prevent adverse interactions. For information on supplements, see the "Additional Interactions" section below.
Consult your healthcare professional about any concerns regarding drug interactions.
The table below highlights some drugs that may reduce Otezla’s effectiveness by accelerating its breakdown in the body:
| Drug or Drug Class | Examples | Potential Impact |
|---|---|---|
| Rifampin | Rifadin | Reduces Otezla effectiveness |
| Certain Seizure Medications | Phenobarbital, Carbamazepine (Tegretol), Phenytoin (Dilantin), Fosphenytoin (Cerebyx), Primidone (Mysoline) | Lower Otezla levels, decreasing efficacy |
| Butalbital-Containing Drugs | Butalbital/Acetaminophen (Butapap), Butalbital/Acetaminophen/Caffeine/Codeine (Fioricet with codeine) | Reduced Otezla effectiveness |
| Enzalutamide | Xtandi | Decreases Otezla levels |
| Lumacaftor/Ivacaftor | Orkambi | May lower Otezla effectiveness |
| Mitotane | Lysodren | Reduces Otezla levels |
Understanding Specific Drug Interactions with Otezla
Seizure Medications
Some seizure drugs speed up Otezla metabolism, lowering its concentration and treatment benefits. If you take seizure medications like phenobarbital or carbamazepine, your doctor may choose alternative therapies.
Butalbital-Containing Headache Medications
Butalbital, found in certain headache prescriptions, can decrease Otezla’s effectiveness by increasing its breakdown. Inform your doctor if you use such medications to explore safer options.
Rifampin (Rifadin)
This antibiotic used for tuberculosis can accelerate Otezla metabolism, reducing its therapeutic effect. Your provider might delay Otezla initiation until rifampin therapy concludes.
Additional Considerations: Supplements, Food, Vaccines, and Tests
Supplements and Herbs
St. John’s wort, an herbal remedy for depression, can diminish Otezla levels by enhancing its clearance. Avoid combining these without medical advice.
Currently, no known interactions exist between Otezla and vitamins, but always consult your healthcare provider before adding supplements.
Food and Vaccines
No documented interactions with food or vaccines have been reported. Discuss any concerns with your doctor.
Lab Tests
Otezla does not interfere with laboratory tests, but inform your healthcare team about all medications you are taking.
Regarding Cannabis or CBD: No known interactions with Otezla exist, but consult your doctor before use. Note that cannabis legality varies by location.
Health Conditions Affecting Otezla Use
Certain health factors may influence Otezla safety and effectiveness. Inform your doctor if you have:
- Severe kidney impairment, which may require dosage adjustments
- Concerns about weight loss, as Otezla can reduce appetite
- Pregnancy or breastfeeding status
- History of allergic reactions to Otezla or its ingredients
- Previous depression or suicidal thoughts, since Otezla may affect mood
Discussing your full medical history helps your provider tailor treatment safely.
Support Resources
If you or someone you know is experiencing a mental health crisis, seek immediate support through resources like the 988 Suicide and Crisis Lifeline or local emergency services.
Frequently Asked Questions About Otezla Interactions
Can Otezla Be Taken with Ozempic?
Yes, no direct interaction is known. Both can cause appetite reduction and weight loss, so monitoring is essential.
Is Ibuprofen Safe with Otezla?
Yes, ibuprofen does not interact with Otezla and may be used concurrently to manage psoriatic arthritis symptoms.
Can Otezla Be Combined with Skyrizi?
There are no known interactions. Sometimes these medications are prescribed together for enhanced treatment of psoriasis or psoriatic arthritis.
Preventing Otezla Interactions
To minimize risks, always:
- Discuss alcohol use and all medications, supplements, and herbs with your healthcare provider
- Notify your doctor if you start new medications during Otezla treatment
- Read all medication guides and labels carefully
- Follow the prescribed dosage strictly
Questions to Ask Your Doctor
Consider asking:
- How will my mental health be monitored while on Otezla?
- Should I inform you about new supplements or medications during treatment?
- Is Otezla safe with my kidney condition?
- Does the dosage affect interaction risks?
Stay informed and connected with support communities to optimize your health journey.
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