Skyrizi Side Effects in 2025: Costs, Risks, and What to Expect

Skyrizi (risankizumab-rzaa) is a prescription medication approved for treating moderate to severe Crohn’s disease, plaque psoriasis, psoriatic arthritis, and ulcerative colitis in adults. While effective, Skyrizi may cause various side effects ranging from mild to serious, including headaches and injection site reactions.

Skyrizi is specifically prescribed for adults with:

• Moderate to severe Crohn’s disease
• Moderate to severe plaque psoriasis
• Psoriatic arthritis
• Moderate to severe ulcerative colitis

Continue reading to explore the common, mild, and serious side effects associated with Skyrizi and tips for managing them. For a comprehensive overview of the medication and its uses, refer to our detailed guide.

Common Side Effects of Skyrizi

Many patients experience mild side effects while on Skyrizi, though some may encounter more serious reactions. The most frequently reported side effects in clinical trials include:

• Upper respiratory infections, such as the common cold
• Headaches
• Fatigue or low energy levels
• Injection site reactions, including bruising, irritation, or itching
• Fungal infections like athlete’s foot or ringworm

If you have concerns about side effects, consult your healthcare provider to understand your personal risk and how to manage symptoms.

Mild Side Effects to Watch For

During treatment, some individuals may experience mild symptoms such as:

• Common cold or upper respiratory infections
• Headaches
• Fatigue
• Injection site discomfort or irritation
• Fungal infections

For a complete list of mild side effects, review the official Skyrizi prescribing information or speak with your doctor.

Serious Side Effects of Skyrizi

Though rare, serious side effects can occur and require immediate medical attention. These include:

• Allergic reactions
• Severe infections

Refer to the “Side Effects Explained” section below for more details.

Frequently Asked Questions About Skyrizi Side Effects

Does Skyrizi cause weight gain?

No, clinical studies did not find weight gain as a side effect of Skyrizi. If you notice unexpected weight changes, discuss them with your doctor who can recommend lifestyle or dietary adjustments.

Is acne a side effect of Skyrizi?

Acne has not been reported as a side effect in clinical trials. Should you experience new or worsening acne, consult your healthcare provider for advice and treatment options.

Are there long-term side effects associated with Skyrizi?

Long-term side effects are unlikely based on current studies. However, Skyrizi may increase infection risk, including serious infections like tuberculosis, which can have lasting effects. Discuss any concerns with your doctor.

Is Skyrizi considered a high-risk medication?

No, Skyrizi is not classified as high risk. High-risk medications typically have a greater chance of causing harm if used incorrectly. For more information about risks, talk to your healthcare provider.

Can Skyrizi lead to hair loss?

Hair loss was not observed in Skyrizi clinical trials. Some other treatments for similar conditions may cause hair loss. If you experience this symptom, your doctor can help you find appropriate management strategies.

Detailed Side Effects Information

Serious Infections

Skyrizi can suppress the immune system, increasing susceptibility to serious infections such as:

• Pneumonia
• Cellulitis
• Osteomyelitis
• Sepsis
• Shingles

Symptoms may include fever, fatigue, cough, or skin changes. Prevent infections by avoiding sick contacts and practicing good hygiene. Contact your doctor immediately if infection symptoms arise.

Fatigue

Fatigue is a common, usually mild side effect that often improves over time. To combat fatigue, maintain a balanced diet, aim for 8 hours of sleep, and engage in regular exercise. Consult your doctor if fatigue persists.

Headaches

Headaches associated with Skyrizi are generally mild and may include tension, sinus, or cervicogenic types. Remedies include staying hydrated, applying warm or cold compresses, and gentle massage. Over-the-counter pain relievers like acetaminophen may help; consult your doctor before use.

Injection Site Reactions

Injection site reactions such as bruising, pain, swelling, or itching are common but typically resolve on their own. Applying a cool compress can provide relief. Discuss persistent or severe reactions with your healthcare provider.

Allergic Reactions

Some individuals may experience allergic reactions ranging from mild skin rashes to severe swelling that can impair breathing. Mild symptoms can often be managed with antihistamines or topical treatments. Seek emergency care immediately for severe reactions.

Tracking Your Side Effects

Keep a detailed log of any side effects during your Skyrizi treatment, noting dosage, timing, symptoms, daily impact, and other medications. Sharing this with your doctor helps tailor your treatment plan effectively.

Important Warnings for Skyrizi Users

Before starting Skyrizi, inform your doctor about any infections, allergies, liver problems, or tuberculosis history. Your healthcare provider may require tests or delay treatment until conditions are managed. Avoid live vaccines during therapy due to immune suppression.

Alcohol Use

Moderate alcohol consumption is generally safe but may trigger psoriasis flare-ups. Discuss alcohol use with your doctor to ensure it aligns with your treatment plan.

Pregnancy and Breastfeeding

The safety of Skyrizi during pregnancy and breastfeeding is not established. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding before starting treatment.

Questions to Discuss with Your Doctor

• What is my risk of side effects with Skyrizi?
• How can I minimize infection risk during treatment?
• Are there any drug interactions I should be aware of?
• What can I do to reduce injection site reactions?

For further information, explore our articles on Skyrizi dosage, cost, interactions, and comparisons with other treatments.

Subscribe to health newsletters and join online support communities like Bezzy for additional resources and peer support.

Ask a Pharmacist

Q:

I have plaque psoriasis and recently developed psoriatic arthritis. Will Skyrizi treat both conditions?

A:

Yes, Skyrizi is approved for both plaque psoriasis and psoriatic arthritis. Consult your doctor to determine if it is the right treatment for your specific health needs.

Disclaimer: This content is for informational purposes only and does not substitute professional medical advice. Always consult your healthcare provider before starting or changing treatment.

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