Kevzara Dosage Guide: Forms, Strengths, Usage Instructions, and More

Kevzara (sarilumab) is a prescription medication designed to manage rheumatoid arthritis and other autoimmune disorders. Administered via injection, it is typically given once every two weeks.

Kevzara can be used alone or alongside other treatments to address:

• Rheumatoid arthritis (RA) in certain adult patients
• Polymyalgia rheumatica in select adults
• Polyarticular juvenile idiopathic arthritis in some children and adults

The active compound in Kevzara is sarilumab, a monoclonal antibody. These lab-engineered molecules mimic natural antibodies, helping the immune system target harmful cells effectively.

This guide outlines Kevzara’s dosage options, strengths, and administration methods. For an in-depth review, refer to our detailed Kevzara article.

Kevzara Dosage Overview

Kevzara is delivered as a subcutaneous injection. Your healthcare provider will instruct you on the proper self-injection technique.

Available Forms of Kevzara

Kevzara is supplied as a liquid solution in prefilled syringes or pens for ease of use.

Strength Options

Kevzara is available in two dosage strengths:

• 150 mg in 1.14 mL
• 200 mg in 1.14 mL

Typical Dosage Regimens

Physicians generally initiate treatment with a lower dose and adjust based on therapeutic response and tolerability, aiming for the minimal effective dose.

Common dosage guidelines include:

For Rheumatoid Arthritis

Adults with RA usually receive 200 mg every two weeks. Dosage adjustments are based on periodic blood test results.

Administration involves injecting the entire content of a 200 mg prefilled syringe or pen every two weeks.

For Polymyalgia Rheumatica

Adults diagnosed with polymyalgia rheumatica typically start with 200 mg every two weeks, combined with a corticosteroid at treatment initiation. Dosage modifications depend on blood test outcomes.

Injection of the full 200 mg dose via prefilled syringe or pen is standard every two weeks.

For Polyarticular Juvenile Idiopathic Arthritis

Adults with this condition generally receive 200 mg biweekly, with adjustments guided by blood tests.

Each dose is administered using a prefilled syringe or pen containing 200 mg in 1.14 mL.

Kevzara Dosage for Children

Kevzara is approved for children weighing 63 kg (approximately 139 lbs) or more to treat polyarticular juvenile idiopathic arthritis. The dosing matches adult recommendations.

Note: Use only the Kevzara prefilled syringe for pediatric doses; the pen is not approved for children.

Consult your child's healthcare provider or pharmacist for personalized dosage guidance.

Long-Term Use

Kevzara is generally prescribed for ongoing treatment. If deemed safe and effective, long-term therapy is common.

Adjusting Dosage

Your doctor may modify your dose based on immune system monitoring and response. For example, a reduction to 150 mg may be necessary if adverse immune effects occur.

Treatment may be paused temporarily during infections.

Factors Influencing Dosage

Several factors affect the prescribed Kevzara dose, including:

• Results from blood tests evaluating immune function
• Your body's response to treatment
• Other existing medical conditions

How to Use Kevzara

After receiving training from your healthcare provider, you’ll inject Kevzara under the skin in areas free from bruising or damage, such as the abdomen or upper thighs. Rotate injection sites to avoid irritation.

A caregiver can also administer injections, including in the upper arm.

For detailed injection instructions, visit the manufacturer’s website or consult your healthcare professional.

Additional information on storage, expiration, and disposal is available in our comprehensive Kevzara article.

Using the Kevzara Prefilled Syringe

Remove the syringe from refrigeration and allow it to reach room temperature for 30 minutes. Ensure the solution is clear before injecting the full contents.

The syringe is suitable for adults and children weighing 63 kg or more.

Using the Kevzara Prefilled Pen

Take the pen out of the refrigerator and let it sit for 60 minutes to reach room temperature. Confirm the solution is clear before injecting the entire dose.

This form is approved only for adults and should not be used for pediatric doses.

Missed Dose Guidance

If you miss a Kevzara dose, inject it as soon as you remember unless the next dose is imminent. Do not double up doses. Inform your healthcare provider about any missed doses.

To help maintain your dosing schedule, consider setting reminders or alarms.

Overdose Protocol

Never exceed the prescribed dose to avoid serious side effects.

In Case of Overdose

If you suspect an overdose, contact your doctor immediately. You can also reach America's Poison Control Centers at 800-222-1222 or use their online resources. For severe symptoms, call emergency services or visit the nearest emergency room.

Disclaimer: This article is intended for informational purposes only and does not replace professional medical advice. Consult your healthcare provider before starting or changing any medication. Drug information may change over time and might not cover all possible uses or precautions.

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