Imfinzi Dosage Guide: Forms, Strengths, Usage Tips & More
Explore the detailed dosage information for Imfinzi (durvalumab), a cutting-edge treatment for various cancers including lung, liver, and endometrial cancer. Understand its forms, strengths, administration schedules, and important usage guidelines.
Imfinzi (durvalumab) is a prescription immunotherapy medication designed to combat specific types of lung, liver, and other cancers. Administered as an intravenous (IV) infusion by healthcare professionals, it is typically given every 2 to 4 weeks depending on the treatment plan.
Imfinzi is approved for adults to treat conditions such as:
- Extensive-stage small cell lung cancer (SCLC)
- Biliary tract cancers, including bile duct cancer
- Unresectable hepatocellular carcinoma (a form of liver cancer)
- Certain non-small cell lung cancers (NSCLC)
- Specific types of endometrial cancer
This medication can be prescribed alone or alongside other treatments like chemotherapy and radiation therapy to enhance therapeutic outcomes.
The active component, durvalumab, belongs to the PD-L1 inhibitor class, which helps the immune system recognize and attack cancer cells.
This comprehensive guide covers Imfinzi’s dosage forms, strengths, administration protocols, and adjustments for varied cancer types.
Imfinzi Dosage Forms and Strengths
Available Form
Imfinzi is supplied as a sterile liquid solution intended for intravenous infusion, administered by a medical professional directly into the bloodstream over a period of time.
Dosage Strengths
Imfinzi is available in two concentrations:
- 500 mg in 10 mL sterile water for injection
- 120 mg in 2.4 mL sterile water for injection
Typical Dosage Protocols
Your prescribed Imfinzi dose depends on factors such as cancer type, body weight, and concurrent treatments. Treatment intervals may vary from every 2 to 4 weeks.
Small Cell Lung Cancer (SCLC)
Adults with extensive-stage SCLC usually receive 1,500 mg of Imfinzi via IV infusion every 4 weeks combined with two chemotherapy agents for approximately 16 weeks (four cycles). Afterward, 1,500 mg of Imfinzi alone is administered every 4 weeks.
Biliary Tract Cancer
Treatment involves 1,500 mg Imfinzi infusions every 3 weeks alongside chemotherapy for up to eight cycles (~24 weeks), followed by maintenance doses of 1,500 mg every 4 weeks.
Hepatocellular Carcinoma (Liver Cancer)
On day 1 of the initial cycle, patients receive 1,500 mg Imfinzi with a single dose of another medication, then continue with 1,500 mg Imfinzi every 4 weeks.
Endometrial Cancer
Patients typically get 1,120 mg of Imfinzi every 3 weeks combined with chemotherapy for six cycles (~18 weeks), followed by 1,500 mg every 4 weeks as monotherapy.
Non-Small Cell Lung Cancer (NSCLC)
Stage 3 NSCLC (Unresectable): Imfinzi is given alone, either as 10 mg/kg every 2 weeks or 1,500 mg every 4 weeks.
Metastatic NSCLC: Patients receive 1,500 mg Imfinzi every 3 weeks alongside other cancer treatments for four cycles, then 1,500 mg every 4 weeks alone.
Long-Term Use and Dosage Adjustments
Duration of Imfinzi therapy varies based on individual response and side effect management. Physicians may pause or discontinue treatment if serious adverse effects arise. Infusion rates can also be adjusted during administration for patient safety.
Factors Influencing Dosage
Dosage decisions consider cancer type and stage, patient weight, and concurrent medications.
Administration Details
Imfinzi is administered via IV infusion in clinical settings, with each session lasting about 60 minutes.
Missed Dose Guidance
If a dose is missed, promptly contact your healthcare provider to reschedule and adjust future appointments as needed. Utilizing reminders can help maintain adherence.
Common Questions About Imfinzi Dosage
How Does Imfinzi Compare to Keytruda Dosages?
While both are PD-1/PD-L1 inhibitors used in cancer treatment, Imfinzi and Keytruda differ in dosage amounts and schedules. Imfinzi is typically administered every 2, 3, or 4 weeks, whereas Keytruda infusions occur every 3 or 6 weeks. Your oncologist will determine the most suitable option.
When Does Imfinzi Begin to Work?
Imfinzi starts exerting effects after the initial dose, but treatment length depends on individual factors including cancer type and response. Regular monitoring by your doctor ensures optimal management.
Disclaimer: This content is intended for informational purposes and is not a substitute for professional medical advice. Always consult your healthcare provider before starting or changing treatments. Drug information may change over time and may not cover all possible uses or side effects.
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