Allegra vs. Claritin: Understanding the Key Differences
University of Illinois Medical Team
Medical Content Specialist #Sexual Wellness
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Allegra vs. Claritin: Understanding the Key Differences

Allegra Allergy and Claritin are popular over-the-counter allergy relief options. Although both help alleviate allergy symptoms, they differ in their active components and other important aspects. Discover how these medications compare to determine which one suits your needs best.

Allegra and Claritin are widely used allergy medications designed to ease symptoms such as sneezing, nasal congestion, and itchy eyes. However, they contain distinct active ingredients: Allegra includes fexofenadine, while Claritin contains loratadine.

Seasonal allergies, commonly known as hay fever, trigger bothersome symptoms like a runny nose, watery eyes, sneezing, and itching. These reactions occur when your body encounters allergens such as:

  • tree pollen
  • grass pollen
  • weed pollen
  • mold spores
  • dust

These allergens stimulate mast cells in the body to release histamine, a chemical that binds to H1 receptors in your nose and eyes. This process causes blood vessels to expand and increases secretions, which is your body's defense mechanism—though it often results in uncomfortable symptoms.

Both Allegra and Claritin are non-prescription antihistamines that block histamine from attaching to H1 receptors, effectively reducing allergy symptoms.

While they function similarly, Allegra and Claritin have notable differences. Let's explore their main distinctions.

Core Characteristics of Allegra and Claritin

Key aspects to consider include the symptoms treated, active ingredients, and available forms.

  • Symptoms addressed: Both medications relieve:
    • sneezing
    • runny nose
    • itchy, watery eyes
    • itchy nose and throat
  • Active ingredients: Allegra contains fexofenadine; Claritin contains loratadine.
  • Available forms: Both come as orally disintegrating tablets, oral tablets, and capsules.

Additionally, Claritin offers chewable tablets and oral solutions, while Allegra provides an oral suspension. These variations are approved for different age groups, which is crucial when choosing a medication for children.

Important: Do not administer these medications to children younger than the approved age for each form.

FormAllegra AllergyClaritin
Orally disintegrating tablet6 years and older6 years and older
Oral suspension2 years and olderNot available
Oral tablet12 years and older6 years and older
Oral capsule12 years and older6 years and older
Chewable tabletNot available2 years and older
Oral solutionNot available2 years and older

For precise dosing instructions, consult the product packaging or speak with a healthcare professional.

Note: Suspensions require shaking before each use, unlike solutions.

Common and Serious Side Effects

Both Allegra and Claritin belong to newer generations of antihistamines, which are less likely to cause drowsiness compared to older types.

Side effects are generally mild and infrequent. Below are examples of potential mild and serious side effects associated with each medication.

Mild Side EffectsAllegra AllergyClaritin
HeadacheYesYes
InsomniaYesYes
Nausea or vomitingYesNo
NervousnessYesYes
Dry mouthNoYes
NosebleedsNoYes
Sore throatNoYes
Serious Side EffectsAllegra AllergyClaritin
Swelling of face, eyes, lips, tongue, throat, or extremitiesYesYes
Difficulty breathing or swallowingYesYes
Chest tightnessYesNo
Flushing or skin rednessYesNo
RashNoYes
HoarsenessNoYes

If you experience any severe allergic reactions, seek emergency medical care immediately.

Important Precautions

When using any medication, consider potential drug interactions and existing health conditions, as these factors differ between Allegra and Claritin.

Drug Interactions

Drug interactions occur when one medication affects the performance of another, potentially causing harm or reducing effectiveness.

Both Allegra and Claritin may interact with ketoconazole and erythromycin. Additionally, Allegra can interact with antacids, while Claritin may interact with amiodarone.

Always inform your healthcare provider about all medications, supplements, and herbs you are taking to avoid harmful interactions.

Health Conditions

Certain health issues require caution when using these antihistamines. Both drugs may pose risks if you have kidney disease. Moreover, specific forms—Allegra’s orally disintegrating tablets and Claritin’s chewable tablets—may be unsafe for individuals with phenylketonuria.

If you have liver disease, consult your doctor before using Claritin.

Expert Recommendations

Allegra and Claritin are effective for allergy symptom relief and are generally well tolerated. Their primary differences lie in:

  • Active ingredients
  • Available formulations
  • Potential drug interactions
  • Safety warnings

Consult your healthcare provider or pharmacist to select the best option for your situation. They can also advise on additional strategies to manage your allergies.

Purchase Allegra here.

Purchase Claritin here.

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