Trintellix Use During Pregnancy and Breastfeeding in 2025: Risks and Considerations

Using Trintellix (vortioxetine) while pregnant or breastfeeding requires careful consideration due to possible risks to both mother and child. The decision to continue or discontinue this medication depends on balancing the dangers of untreated depression against potential side effects during these critical periods.

Trintellix and Pregnancy Risks

Research indicates that Trintellix may pose risks to newborns, especially when taken in the third trimester. Exposure during this stage can increase the likelihood of serious respiratory issues in infants, potentially necessitating breathing support, extended hospitalization, or tube feeding.

Additionally, infants exposed to Trintellix late in pregnancy might experience withdrawal symptoms such as hypoglycemia, tremors, and prolonged crying episodes.

However, discontinuing Trintellix abruptly during pregnancy can lead to a relapse of major depressive disorder, which carries its own significant risks for both mother and baby.

To better understand the effects of antidepressants like Trintellix during pregnancy, the National Pregnancy Registry for Antidepressants collects valuable data. Expectant mothers using antidepressants can enroll through their healthcare provider by calling 844-405-6185 or visiting the registry's website.

If you are pregnant or planning to conceive while on Trintellix, consult your healthcare provider to carefully evaluate the benefits and risks of continuing, adjusting, or stopping treatment.

Trintellix and Breastfeeding Considerations

Currently, it is unclear whether Trintellix passes into human breast milk or impacts milk supply and infant health. Animal studies have detected the drug in milk, but these findings do not always translate directly to humans.

For mothers who are breastfeeding or planning to breastfeed, discussing the potential advantages and drawbacks of Trintellix use with a healthcare professional is crucial to ensure safety for both mother and child.

Disclaimer: This content is intended for informational purposes only and does not replace professional medical advice. Always consult a licensed healthcare provider before making decisions about medications during pregnancy or breastfeeding. Drug information is subject to change and may not cover all possible scenarios or side effects.

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