CBD Oil for Seizures 2025: Price, Effectiveness, Side Effects & Latest Research
Explore the latest 2025 insights on CBD oil for seizures, including its approved uses, effectiveness against rare epilepsy forms, potential side effects, and how it compares to other treatments.
Seizures result from abnormal electrical activity in the brain and can stem from various causes such as:
- Epilepsy
- Brain infections
- Electrolyte imbalances
- Sleep deprivation
- Traumatic brain injury
- Drug overdose
Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, is gaining attention for its potential to manage seizures without the intoxicating effects of THC.
This article dives into the most recent studies on CBD oil’s role in seizure control, its effectiveness, and possible side effects.
How Does CBD Oil Help Control Seizures?
While the exact mechanism remains under study, CBD interacts with the body's endocannabinoid system—a network involved in regulating appetite, sleep, pain, and immune responses.
Research suggests CBD may reduce neuron excitability by targeting specific receptors, such as GPR55 and TRPV1, which could explain its antiseizure properties.
The FDA has approved the prescription CBD medication Epidiolex for treating seizures linked to Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex.
Effectiveness of CBD Oil for Seizures
Extensive clinical trials have focused on these three conditions where Epidiolex has demonstrated significant benefits.
Lennox-Gastaut Syndrome
Accounting for 2-5% of childhood epilepsy cases, Lennox-Gastaut syndrome patients showed notable seizure reduction in two 14-week studies:
Study One
- Participants taking 20 mg/kg of Epidiolex daily experienced a 44% reduction in seizures.
- The placebo group saw a 22% reduction.
Study Two
- 20 mg/kg dose led to a 42% seizure decrease.
- 10 mg/kg dose resulted in a 37% decrease.
- Placebo group had a 17% reduction.
Dravet Syndrome
In children aged 2 to 18, a 20 mg/kg daily dose of Epidiolex reduced seizure frequency by 39%, compared to 17% in the placebo group.
Tuberous Sclerosis Complex
This genetic disorder causes benign tumors that can trigger seizures. A trial with 148 patients showed a 48% median seizure improvement with Epidiolex versus 24% with placebo.
Other Seizure Types
Preliminary research indicates CBD may boost the effectiveness of certain epilepsy medications like clobazam. A 2018 study involving rare epileptic syndromes revealed a drop from an average of 59.4 seizures per month to 22.5 after 12 weeks, sustained over 48 weeks.
Optimal Use of CBD Oil for Seizures
Always consult a healthcare provider before starting CBD for seizures to manage potential drug interactions and monitor seizure frequency.
Epidiolex dosing typically begins at 2.5 mg/kg twice daily, increasing to 5 mg/kg, and potentially up to 10 mg/kg twice daily based on response.
Discontinuing CBD abruptly can increase seizure risk; gradual adjustments under medical supervision are essential.
Interactions Between CBD and Seizure Medications
CBD may interact with several antiepileptic drugs, potentially altering their effectiveness or side effects. Notable medications include:
- Brivaracetam
- Clobazam
- Eslicarbazepine
- Stiripentol
- Rufinamide
- Topiramate
- Valproic acid
- Zonisamide
Both CBD and some seizure medications carry a rare risk of increasing suicidal thoughts, so medical oversight is crucial.
Potential Side Effects of CBD for Seizures
- Sleepiness
- Drowsiness
- Diarrhea
- Loss of appetite
Combining CBD with certain drugs may elevate liver damage risk. Since commercial CBD products lack FDA regulation, they may contain contaminants or inconsistent dosages, underscoring the importance of third-party tested products.
Some studies report increased seizures with cannabis products, highlighting the need for caution.
Recommended CBD Products and Strains for Seizures
Research suggests full-spectrum cannabis products rich in CBD might reduce seizures more effectively than pure CBD alone, but more evidence is needed.
A 2020 study found commercial CBD users experienced a 70% increase in seizures, whereas Epidiolex users saw a 39% decrease, likely due to higher THC levels in commercial products.
Epidiolex’s FDA approval ensures consistent quality and dosage, unlike many over-the-counter CBD oils.
Consult Your Doctor Before Using CBD Oil
Discussing CBD use with a healthcare professional is essential to tailor treatment, avoid harmful interactions, and track progress effectively.
Summary
CBD oil is a promising treatment for seizures related to rare epilepsy forms and tuberous sclerosis complex, with ongoing research exploring broader applications.
Due to potential risks, including increased seizure frequency with some cannabis products, medical guidance is vital before starting CBD therapy.
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