Camzyos Side Effects Uncovered: Essential Insights and Management Tips

Camzyos (mavacamten) is an FDA-approved oral capsule designed to treat obstructive hypertrophic cardiomyopathy (HCM) in adults, a condition characterized by thickened heart muscles obstructing blood flow. While effective, Camzyos may cause a spectrum of side effects, ranging from mild dizziness to more serious heart-related complications.

Primarily prescribed to adults experiencing symptoms during physical activity due to obstructive HCM, Camzyos works by modulating cardiac myosin to improve heart function.

Continue reading for an in-depth look at the common, mild, and serious side effects associated with Camzyos, and learn how to manage them effectively. For a broader understanding of the drug’s uses and mechanism, refer to our detailed Camzyos overview.

Critical Safety Alert: Heart Failure Risk

Camzyos carries a boxed warning—the FDA’s highest safety alert—due to the potential risk of heart failure. This warning emphasizes the importance of careful monitoring during treatment.

Further details are provided in the “Side Effects Explained” section below.

Common Side Effects of Camzyos

Patients may experience side effects ranging from mild to severe. The most frequently reported include:

• Dizziness*
• Fainting

*See the detailed explanation below for more information on dizziness.

Mild Side Effects to Watch For

Some patients report mild reactions such as:

• Dizziness*
• Fainting
• Mild allergic responses*†

These symptoms are typically temporary and manageable. However, persistent or troubling symptoms should prompt consultation with a healthcare provider. Never discontinue Camzyos without medical advice.

*Refer to the “Side Effects Explained” section for further details.
† While allergic reactions are possible, they were not observed in clinical trials.

Serious Side Effects Requiring Immediate Attention

Serious adverse effects reported include:

• Boxed warning: risk of heart failure*
• Severe allergic reactions*†

If you experience these symptoms, contact your healthcare provider immediately. In emergencies, call 911 or your local emergency services.

*See the “Side Effects Explained” section below for comprehensive information.
† Severe allergic reactions were not reported in studies but remain a potential risk.

Post-Approval Monitoring: The FDA continuously monitors Camzyos for side effects. To report any adverse reactions, visit the MedWatch website.

Frequently Asked Questions About Camzyos Side Effects

Here are answers to common questions regarding Camzyos’ side effect profile.

How Do Camzyos Side Effects Compare to Beta Blockers Like Coreg?

Coreg (carvedilol) is a beta-blocker also used to alleviate obstructive HCM symptoms. Both Camzyos and beta-blockers can cause dizziness and heart failure, but beta-blockers may additionally lead to fatigue, bradycardia (slow heart rate), and hypotension (low blood pressure).

Discuss with your doctor which medication suits your condition best, considering their side effect profiles.

Are There Long-Term Side Effects Associated with Camzyos?

Current studies have not identified long-term side effects linked to Camzyos. If you have concerns about prolonged use, consult your healthcare provider for personalized guidance.

Side Effects Explained in Detail

Heart Failure Risk

Camzyos’ boxed warning highlights the potential for reduced ejection fraction, a measure of the heart’s blood-pumping efficiency, which can lead to heart failure. Symptoms of heart failure include:

• Shortness of breath
• Fatigue
• Swelling in legs or feet
• Chest pain
• Heart palpitations
• Irregular heartbeat
• Rapid weight gain

Risk factors that may increase heart failure likelihood include serious infections, irregular heart rhythms, grapefruit juice consumption, and interactions with certain medications such as disopyramide, ranolazine, verapamil, diltiazem, itraconazole, clarithromycin, ritonavir, omeprazole, esomeprazole, and cimetidine.

Preventive Measures

Camzyos is available exclusively through a Risk Evaluation and Mitigation Strategy (REMS) program to ensure safe use. Prescribing doctors and specialty pharmacies must be REMS-certified.

Regular echocardiograms are mandatory before and during treatment to monitor heart function. Avoid grapefruit juice and consult your doctor before combining Camzyos with other medications, including supplements and herbal products.

If heart failure symptoms emerge, contact your healthcare provider promptly; discontinuation of Camzyos may be necessary.

Dizziness

Dizziness is commonly reported and may be accompanied by light-headedness or nausea, sometimes leading to fainting. These symptoms can also be manifestations of obstructive HCM or heart failure.

Factors increasing dizziness risk include grapefruit juice, alcohol, and drug interactions similar to those listed under heart failure risk.

Management Tips

Avoid grapefruit juice and consult your healthcare provider before taking additional medications. If dizziness worsens, your doctor may adjust your dosage or order heart function tests.

Allergic Reactions

Though rare and not observed in clinical trials, allergic reactions to Camzyos can range from mild rashes and itching to severe swelling affecting breathing.

What to Do

For mild symptoms, contact your doctor who may recommend antihistamines or topical treatments. Severe symptoms require immediate emergency care. Your doctor will determine whether to continue or discontinue Camzyos based on reaction severity.

Tracking Side Effects

Keeping a detailed record of any side effects—including dosage, timing, symptoms, impact on daily life, and concurrent medications—can aid your healthcare provider in optimizing your treatment plan.

Important Precautions Before Starting Camzyos

Boxed Warning Reminder

Remember the serious heart failure risk associated with Camzyos as detailed above.

Additional Warnings

Discuss your full medical history with your doctor, especially if you have:

• Existing heart failure
• Irregular heart rhythms
• Liver issues
• Previous allergic reactions to Camzyos
• Are pregnant or breastfeeding

Always consult a healthcare professional before initiating Camzyos therapy.

Disclaimer: This content is for informational purposes only and does not replace professional medical advice. Always consult your healthcare provider for guidance tailored to your health condition.

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